Introduction: An uneventful cataract surgery can lead to retinal changes including subclinical cystoid macular oedema. The use of NSAID preoperatively and steroids and NSAID combination postoperatively reduces the incidence of pseudophakic cystoid macular oedema. Objective: To compare the effect of post-cataract surgery topical NSAID (bromfenac 0.09%) plus steroid (prednisolone acetate 1% ) use to that of topical steroid (prednisolone acetate 1% ) use alone on central macular thickness assessed by Optical Coherence Tomography (OCT). Methods: A prospective, observational, comparative study including 100 eyes of 100 patients who underwent uncomplicated Small Incision Cataract Surgery with PCIOL implantation. Among these, 50 operated eyes of 50 patients were started postoperatively on topical bromfenac 0.09% with prednisolone acetate 1% (Group 1) and 50 operated eyes of other 50 patients were started postoperatively on topical Prednisolone acetate 1% alone (Group 2). The patients were randomly distributed into two groups. The Subfoveal thickness, Parafoveal thickness and Perifoveal thickness of macula on OCT of both groups were noted preoperatively a day before surgery and postoperatively at Day1, 2weeks and 4weeks. Results: The study included sixty males and forty females.33.0% patients belonged to 50-59 years, 42.0% to 60-69 years and 25.0% to 70-79 years. There was a statistically significant increase in mean Subfoveal thickness, mean Parafoveal thickness and mean Perifoveal thickness in Group 2 patients as compared to Group 1 patients postoperatively at 2 weeks and 4 weeks. Conclusion: The central macular thickness in the early postoperative period is significantly less in patients on postoperative topical NSAID and steroid as compared to those on postoperative topical steroid alone. Adding a topical NSAID to a topical steroid postoperatively has a beneficial effect on Central macular thickness.