Background: Atrial fibrillation (AF) is one of the known complications of cardiac surgery and represents a major cause of morbidity. However, improvements in surgical and anaesthesia technique and controlling various predisposing factors have not helped to curb the incidence. Therefore, search is going on for various modalities to decrease the incidence. Aim: This retrospective study was conducted to evaluate the risk of AF with nebulised __ampersandsignszlig;2 agonists in postoperative cardiac bypass surgery patients. Methods: In this observational study, data of 100 eligible patients operated for coronary artery bypass grafting (CABG) was collected. Patients were divided in two groups: Group A: Patients who had received postoperative nebulised salbutamol Group B: Patients who had not received postoperative nebulised salbutamol The data was analyzed for onset, duration, severity, treatment, outcome of post operative AF (POAF) and also regarding dose, duration of salbutamol. Results: POAF occurred frequently in patients who had received nebulised salbutamol (p__ampersandsignlt;0.05). ICU and hospital stay was also prolonged in Group A. However, none of the patients had fatal postoperative complication. Conclusion: Salbutamol nebulisation in post CABG patients could be an additional risk factor for POAF.