Objective: To compare salivary flow __ampersandsignamp; candida carriage in patients with oral submucous fibrosis (OSMF) as OSMF causes a reduction in salivary flow making odontogenic structures caries prone __ampersandsignamp; increasing in candida causing oral thrush, angular chelitis__ampersandsignamp; in some cases malignancies. Material __ampersandsignamp; Methods: A total of 40 subjects were included in the study __ampersandsignamp; divided into 2 groups. The 1st group included patients without OSMF __ampersandsignamp; the 2nd group included patients with OSMF. The duration of the study was 1 year. For every subject, inter incisal distance was measured using vernier callipers. The saliva sample was collected in pre-weighed cotton rolls __ampersandsignamp; the difference was noted. A separate saliva sample was collected __ampersandsignamp; inoculated on chrome agar for candida growth. Descriptive statistics like mean, median __ampersandsignamp; standard deviation were used to summarize the variable. Differences in the mean across the groups were tested by Student__ampersandsignrsquo;s t-test. Results: The difference in salivary flow was statistically significant at a 5% level of significance (P-value __ampersandsignlt; 0.000). The control group did not show candida growth. In contrast, the OSMF group showed the presence of candida in 16 out of 20 samples. Conclusion: Salivary flow was decreased significantly __ampersandsignamp; candida carriage was increased significantly in patients with OSMF as compared with healthy control group subjects. As the grades of OSMF increased, the salivary flow was decreased __ampersandsignamp; candida carriage was increased.