Introduction: Spinal cord injury is a devastating condition making most of the affected population wheelchair-bound. Moreover, affecting cardio-respiratory functioning and the overall life quality of an individual. Sports has been an evident and widely accepted means to strengthen all body systems. Materials __ampersandsignamp; Methods: A comparative cross-sectional study with two groups of sports players and non-players with Spinal cord injury [sample size (n) = 34, for each group] with a mean age of 28.5__ampersandsignplusmn; 3.956 in players groups and 31.24__ampersandsignplusmn; 5.217 in non-players group, were selected. Quality of life was measured using the WHOQOL BREF questionnaire (including 4 domains i.e. Physical health, Psychological health, Environmental health and social relationships). Physical health parameters included Resting heart rate, Physiological cost index and Muscular endurance. Respiratory parameters (FEV1%, FVC% and MVV %) were recorded using a computerized spirometer (minister model). Results: In the independent t-test, the Quality of life domains showed a statistically significant difference in the Physical health domain (p=0.007), Psychological health domain (p=0.00) and Environmental domain (p=0.021) while not in the Social relationships domain (p=0.889). Among respiratory parameters; FEV1% (p=0.022), FVC % (0.04) showed statistically significant differences while no significant difference in MVV% was predicted. Among Physical health parameters, the Physiological cost index (p=0.00), Resting heart rate (p=0.01) and Muscular endurance (p=0.01) showed significant differences. Conclusion: The present study concluded that the overall Quality of life of sports players with spinal cord injury (paraplegic) is improved. Due to participation in sports and training; muscular endurance improved, the Physiological cost index of wheelchair propulsion and Baseline heart is decreased.