Introduction: CL/CPof neonates may be prevented by identification of genetically susceptible parents through identification of parent__ampersandsignrsquo;s ectodermal markers. Objective/Aim: To identify any specific pattern of Finger Print, Lip Print and Palatal Print among Bengali parents of children with non-syndromic CL__ampersandsignamp;CP which can be considered as a genetic marker in the transmission of CL __ampersandsignamp; CP to their offspring. To determine the predominant finger, lip and palatal print pattern in a healthy Bengali ethnic population. Study Design and Methodology: The present observational, case-control study was performed among 66study subjects, (parents of children with CL__ampersandsignamp;CP), and 66 control subjects, (parents of children without CL__ampersandsignamp;CP) of Bengali ethnicity. Dermato glyphics, Cheiloscopy and Rugoscopy were performed by ink and paper method, direct photography and impression techniques respectively. Available data were statistically analysed using the Chi-square test and T-test. Result: Study group exhibited increased asymmetry and ulnar loop Fingerprint pattern, higher Type IIa and type O lip print pattern than the control group. Wavy pattern palatal print was the most predominant pattern for both study and control groups. Among the healthy Bengali ethnic population (control group) dominant Finger Print - whorl, Lip Print - Type IIc, Type I and palatal Print - wavy was demonstrated. Conclusion: Increased asymmetry with higher loop patterns in Dermatoglyphics and increased Types IIa, O patterns in Cheilos copy can be considered as genetic markers for the transmission of CL__ampersandsignamp;CP deformity to offspring in the Bengali populatio