Introduction: Post-mortem studies provide important information for understanding the new disease pathogenesis and clinical outcomes. Methods: Post-mortem examinations were performed according to WHO guidelines brought dead at tertiary care hospital, Tamilnadu, India. Tissues from the lung, heart, liver, kidney, spleen, and brain were examined. Results: Lung findings revealed early-stage DAD in 6 out of 10 cases and late-stage DAD in 4 cases, atypical pneumocytes and bronchopneumonia also noted. There is no evidence of myocarditis, hepatitis or encephalitis. Microvascular injury and thrombosis were also detected. Conclusion: The SARS-CoV-2 infection causes multisystem disease and significant pathological changes seen in most organs in patients with and without comorbidities irrespective of age.