Introduction: Acute pancreatitis is an inflammation of the pancreas, due to alcohol or gallstones. Severe pancreatitis may lead to higher morbidity and mortality. Early, an efficient and structured scoring system is required to know the potential outcome of the patient. Aims: The study aims to assess the accuracy of the bedside index for severity in acute pancreatitis (BISAP) and Ranson__ampersandsignrsquo;s scoring system and to compare both in predicting the severity of acute pancreatitis. Methodology: This is a cross-sectional observational study of 90 patients with acute pancreatitis admitted to GSL medical college and general hospital, Rajahmundry. Results: The mean age of the study group was 38.34 __ampersandsignplusmn; 10.41 years. Of the total 90 patients, 47 patients had mild disease, 27 patients had moderately severe courses, and 16 patients had severe courses. Renal failure was the most common organ dysfunction in severe acute pancreatitis and the Mortality rate in this study was 1.1%. Ranson__ampersandsignrsquo;s score had a sensitivity of 93.75% (95% CI 69.77%--99.84%), specificity of 94.59% (95% CI 86.73%--98.5%). BISAP score had a sensitivity of 87.5% (95% CI 61.65% -- 98.45%), specificity of 98.6% (95% CI 92.7% -99.97%). Conclusion: Ranson__ampersandsignrsquo;s score had a higher sensitivity and BISAP had higher specificity in the prediction of severe pancreatitis. Components of the BISAP scoring system are easily available when compared to Ranson__ampersandsignrsquo;s scoring system as the latter may require 48 hours for completion of the assessment.