Introduction: Acute kidney injury(AKI) is a common complication after acute myocardial infarction (AMI), affecting 10 to 55% of the patients.1-4 The mechanisms causing AKI in the first few days after an AMI are multifactorial, including systemic and renal hemodynamic changes secondary to an impaired cardiac output and an imbalance of vasodilators and vasoconstrictors, the use of contrast media, and immunological and inflammatory kidney damage resulting from crosstalk between the heart and the kidney Material and Methods: The study was conducted on 224 ST-segment elevations myocardial infarction (STEMI) patients admit ted to a tertiary care hospital during December 2018-December 2020. The patients were divided into two groups depending on the development of AKI according to KDIGO (Kidney disease improving global outcomes) guidelines. Results: Out of 224 patients, 57 patients (25.45%) developed AKI and 167 patients (74.55%) did not develop AKI. So, the incidence in our study was 25.45%. When various risk factors were compared in both the group__ampersandsignrsquo;s diabetes and higher BMI (body mass index) were found to be significantly associated with AKI. The mortality in the AKI group was 28.07% while in the non-AKI it was 1.79%. In-hospital complications like cardiogenic shock left ventricular failure (LVF), arrhythmias were associated with increased incidence of AKI. Using multiple logistic regression analysis, age, presence of diabetes, tachycardia on admission, raised blood sugar on admission, decreased ejection fraction (EF), presence of cardiogenic shock and arrhythmia were independent risk factors for AKI. Conclusion: AKI in STEMI was associated with increased mortality and complications.