Introduction: Alzheimer__ampersandsignrsquo;s type sporadic dementia was induced in rats by intracerebroventricular (ICV) to the lateral ventricle of the brain using robotic stereotaxic apparatus. Aims: The present study was aimed at evaluating the neuroprotective effect of extract of Cleome viscosa Linn. against coach cine-induced dementia in rats. Methodology: For this experiment, male Wistar rats were used and were administered with ICV injection of colchicine and methanol extract of Cleome viscosa (100 or 200 mg/kg. p.o) for 3 weeks to determine the preventive effect of extract against colchicine toxicity. Exposure to colchicine produced oxidative stress in rats and model for memory deficit. The spatial memory of animals was evaluated using Morris water maze followed by biochemical estimation of acetylcholinesterase in the hippocampal and frontal cortex region of the brain. Results: Exposure to colchicine produced oxidative stress in rats and model for the deficit in memory in rats. The level of acetylcholine esterase was not significantly changed in the hippocampal region and the frontal cortex region in the extract-treated groups. And also failed to exert any protective effect against colchicine induced dementia was evaluated using Morris Water Maze for parameters related to Path efficiency, Escape Latency, D quadrant latency followed by biochemical estimation of Acetylcholinesterase (AChE) enzyme level in the frontal cortex and Hippocampal region of rat brain. Conclusion: The current study suggests the inability of methanol extract of Cleome viscosa used at this dose to provide neuroprotective action in ICV injected Colchicine induced sporadic model of Alzheimer__ampersandsignrsquo;s disease model in rats.