Background: In the past few decades stress has been considered a major problem in medical students__ampersandsignrsquo; life. Sleep abnormality is associated with cognitive function abnormalities. Stress is one of the prevalent factors which worsen sleep quality. Aim: This study aimed to estimate the sleep quality of first-year medical students owing to perceived stress. Method: This study was conducted after due approval from the institutional ethics committee. It was a cross-sectional study that included 144 subjects including 87 male and 57 female. Stress was assessed by perceived stress scale (PSS) and sleep quality was assessed by indicators designed by National Sleep Foundation (NSF). A P-value less than 0.05 was considered to be significant. Result: 70.8% of subjects perceived moderate stress, 19.2% of subjects perceived low stress and 16% of subjects perceived high stress. On analysis, we found that some subjects sleep quality was inappropriate and most of them perceived severe stress. Conclusion: Poor sleep quality was associated with severe stress in first-year medical students. This may affect the cognitive function that affects the carrier building.