Introduction: Considering the rise in the number of health research activities amid the ongoing coronavirus disease-2019 pandemic, there is an immense need to understand the knowledge, attitude and practices of the medical researchers on the informed consent documentation process in their research studies. Academic research in medical colleges is booming for two exclusive reasons, namely, the need for research papers for academic promotions, and the student projects guided by the faculty. Objective: To determine the knowledge, attitude and practices about the Informed consent documentation (ICD) process among researchers in medical colleges. Methods: This was a cross-sectional survey done using an online questionnaire among 241 researchers in various medical colleges for their knowledge, attitude and practice on the process of ICD in their research. Results: About 91.5% of them were aware of the importance of informed consent, 85.9% believe that the ICD process safeguards the rights of the research participants and nearly 92.5% practised obtaining informed consent from the participants in their projects. Statistically significant results (p__ampersandsignlt;0.05) was found in certain intricate practices of ICD among senior faculties when compared against the junior faculties. However, the association between designation and knowledge is not much evident in this study. Conclusion: Researchers are aware of the importance of ICD in all aspects however there is a good segment of them who need training and guidance on the process of ICD to achieve complete compliance of ICD at all levels of researchers in medical colleges.