Aim: The study was aimed to compare the efficacy of Trans Abdominal Plane (TAP) block with port site infiltration on postoperative pain and analgesia requirement in patients undergoing laparoscopic cholecystectomy. Methods: The Prospective observational study was conducted at SKIMS Medical College Hospital over 1 year. A total of 112 subjects between 20 to 70 years of age with the American Society of Anaesthesiologists(ASA) physical status I/IIundergone laparoscopic cholecystectomy were included. The patients were divided into two groups using computer-generated random numbers; Group A included patients who received Ultrasound-guided bilateral subcostal transabdominal plane (TAP) block and Group B included patients who received port-site infiltration. The patients were assessed for pain in the first 24hours period using the Visual analogue pain scale (VAS) at 0,2,6,12 And 24hours. The data was collected and analyzed. Results: Among 112 patients who met the inclusion criteria, 37.5% were males with a male: female ratio of 0.6. The maximum number of patients were in the age group of 40-50years (41.05%) with the mean age in the TAP group 43.96 years and port-site infiltration group 44.74 years. There was no statical differences between the two groups and were comparable in gender, age and American society of anaesthesiology(ASA) physical status. At 24 hours, subjects with TAP blockhead had a mean VAS score less than the port site infiltration group (0.2 vs 0.4). The overall VAS Score was significantly lower in TAP block subjects (p-value of 0.0011). No significant statistical difference with regards to time to oral intake, ambulation after surgery and hospital discharge was found between the two groups of patients. All the patients did well and were fully satisfied. Conclusion: Ultrasound-guided TAP block is an effective, safe, efficient and satisfactory method of analgesia after laparoscopic cholecystectomy. Port-site infiltration also improves the postoperative outcome but is less efficient than TAP block in laparoscopic cholecystectomy.