Introduction: Dermatoglyphics is the study of epidermal ridge patterns on the fingers, palms, and soles. The correlation of dermatoglyphic patterns with many chromosomal abnormalities and genetic diseases is evidenced by many researchers in the world. As type two diabetes mellitus (DM) has the strong genetic background, the dermatoglyphic study can be useful as a screening tool in early diagnosis and to find out the persons are at risk. Aims: To compare the angle between axial and digital triradius (and angle-angle between line drawn from axial triradius t at base of palm between the thenar and hypothenar eminences to triradius __ampersandsignlsquo;a__ampersandsignrsquo;- at base of index finger and to -triradius at base of little finger) between type 2 DM patient and sex-matched control group. Case Report: A case-control study was done among 200 types two DM patients of 40-60 years of age as case and 200 sex matched control groups. The palmar prints were collected by ink method and at angles of each print were measured. Data were analyzed revealing mean and standard deviation and tested by student__ampersandsignrsquo;s t-test, taking p-value __ampersandsignlt; 0.05 as statistically significant. Discussion: Statistically significant changes are observed in the mean atd angle of the left hand of a type 2 diabetes patient (42.62__ampersandsignplusmn;0.206 with S.D 2.91) compared to control (42.13__ampersandsignplusmn;0.20 with S.D 2.83). CONCLUSIONS: Increased atd angle of the left hand in presence of risk factors for the development of type two diabetes mellitus is a strong predilection for the development of the disease