Introduction: Diabetic peripheral neuropathy is the most common complication of diabetes, and can occur in all diabetics regardless of the type. Its diagnosis is clinical, with suggestive history and neurologic examination. Altering the natural history and administering symptomatic treatments are the hallmark of management, but many systems of medicine tried to target multiple pathways have not shown promising results. Hence, options in Ayurveda may be sought. Case Report: A 49-year-old female patient who presented with numbness over her lower limbs associated with tingling sensation since the past year and who was diagnosed case of diabetic peripheral neuropathy is presented here. She underwent an inpatient treatment protocol, which included oral medicines and external therapies. Results: Michigan Neuropathy Screening Assessment showed a 50% improvement in the history questionnaire and 80 % improvement in physical examination. In the biothesiometry readings, there was an improvement in vibratory perception by 25 % and 50% in right and left leg respectively. Conclusion: This case illustrates the potential of an Ayurvedic treatment protocol to manage peripheral diabetic neuropathy.