On an extensive panel of purulent-inflammatory, bronchopulmonary, and various other human diseases, the organismic and immuno-metabolic role of low-molecular-weight RNA, the state of oxidation of lipids, proteins, factors of the antioxidant system, and metabolic syndrome were studied. The relationship between clinical and laboratory parameters (haematological, biochemi cal, neurological, endocrine, and immune) has been analyzed. The effectiveness of modulators and antioxidants is discussed, and the pronounced laboratory-clinical activity of the drug combination is shown.