Aim: To compare and evaluate the antifungal effect of origanum oil and povidone-iodine aqueous solution on scleral resin. Introduction: Ocular prosthesis being a part of maxillofacial prosthodontics aims to restore and repair the ophthalmic cavity. An important prerequisite for a prosthesis is the eradication of plaque accumulation due to bacteria. To neglect probable infections in the patient__ampersandsignrsquo;s ophthalmic cavity a naturally available antifungal agent was tested in this study. Methods and Material: In this study, 40 custom made scleral resin disks (20 in each group) immersed in 2 different solutions were studied for their antifungal activity. The evaluation of this property was done by calculating the zone of inhibition around the disks propelled in the specific agar media. Statistical Analysis: Descriptive and analytical statistics were done. The data is represented in mean and standard deviation. The normality of continuous data was analysed by the Shapiro-Wilk test. As the data followed a normal distribution, parametric tests were used to analyse the data. The independent sample t-test and paired sample t-test were used to check to mean differences. The level of significance was kept at p__ampersandsignlt;0.05. The software used wasSPSS (StatisticalPackagefor Social Sciences) Version 24.0 (IBM Corporation, Chicago, USA) Results: The antifungal efficacy of the origanum oil solution was found to be significantly higher than the povidone-iodine solution. Conclusion: This study concluded that origanumoil is a potent antifungal against C. Albicans. This encourages the researcher to assess the effectiveness of O. vulgare oil in other forms of systemic and superficial fungal infections as well as to investigate its broad-spectrum outcome against other pathogenic manifestations which also include malignancies.