Introduction: Coronavirus (COVID-19) illness, which has been labelled a pandemic, was caused by the year 2019. It was labeled a worldwide emergency on January 30th, 2020. Objective: To assess the knowledge and practices about the covid-19 pandemic in Pakistan Material and Methods: From April 1, 2021, to May 6, 2021, a cross-sectional online survey was performed. Residents of Punjab and Baluchistan, Pakistan, who were 18 or older male and female could read and understand English and Urdu who had completed the entire questionnaire were the subjects of the study. A structured close-ended online questionnaire based on expert opinions and literature was used to collect data. Software Statistical Package for Social Sciences (SPSS) version 21.0 was used to analyse the data. Results: The maximum number of the participants 330 (88.2%) were aware of the existence of coronavirus disease and there is no relationship between the categorical variables of gender (p= .144; p__ampersandsigngt; .000). The majority of females 78 (20.8%) always, 72 (19.2%) often washed their hands with soap for twenty minutes significantly higher than males 52 (13.8%) 64 (17.0%) that indicates p__ampersandsignlt; .001. Similarly, the majority of females used ordinary mask 94 (25.0%) always, 46 (12.2 %) often as compared to males 56 (14.3%); always, 59 (15.7) often and the majority of participants 345 (85.0%) were practising the general SOPs and value of p __ampersandsignlt;.001 for gender association. Conclusion: The participants from Punjab and Baluchistan have a better understanding of the COVID-19 and most of the participants are practising SOPs. However, more awareness is needed to improve the situation and stop the virus from spreading.