Introduction: Although myocardial infarction is often depicted as a modern disease it was recognized before the modern era. There were references to what could be recognized today as angina pectoris, myocardial infarction and sudden death in ancient Egyptian, Greek, Biblical and the lmudic sources. Coronary angiogram performed 6-9 days showed patent vessel in all patients of group-I as compared to only 2 patients of group-II. Ejection Fraction (EF) increased from 38% to 47% in group I as compared to unchanged 40% as assayed by gated b ejection fraction lood pool imaging after 35 days. Aim: The aim here is to compare the outcome of patients with ST-Segment Elevation Myocardial Infarction (STEMI) myocardial infractions in diabetics and non-diabetics. Method: The method that we have adopted for our research is carried on patients admitted to the Medical Intensive Care Unit (MICU) of Krishna Institute of Medical Sciences, Karad over 18 months from October 2018 to March 2020. This study was approved by the institutional ethics and protocol committee. Protocol number 0257/2018-2019. Result: We studied 160 patients, 80 nondiabetic and 80 diabetic patients of __ampersandsignlsquo;ST__ampersandsignrsquo;- Segment myocardial infarction in Krishna institute of medical sciences and research centre, Karad. Out of 160 patients in the present study majority of the cases were from 60-69(38.8%) years of age. Duration of hospital stay was significantly higher in diabetic patients compared to non-diabetic patients (p=0.023). No significant difference was observed in the final outcome (deaths and discharge) between the two groups. Conclusion: Failed thrombolysis in acute myocardial infarction was more in diabetic __ampersandsignlsquo;ST__ampersandsignrsquo; segment elevation myocardial infarction patients as compared to non-diabetic __ampersandsignlsquo;ST__ampersandsignrsquo; segment elevation myocardial infarction patients. Even when promptly receiving thrombolytics, the outcome in the diabetic group, both in terms of mortality and morbidity was worse as compared to the nondiabetic group.