Introduction: Chemotherapy is one of the most commonly used treatments of choice for cancer and it leads to certain side effects. The oncology care team needs to identify the symptoms experienced by cancer patients who are under chemotherapy to resolve these side effects. Objective: To identify the most common side effects experienced by cancer patients undergoing chemotherapy. Methods: A cross-sectional survey is carried out in the Medical Oncology Outpatient department and Chemotherapy Units of Sri Ramachandra Hospital, Sri Ramachandra Institute of Higher Education, and Research (DU), Chennai, India, from February to March 2020. A convenient sampling technique was used to recruit a total of 150 cancer patients. Data collection was done through personal interviews and a review of their medical records. Approximately 15-20 minutes was required to obtain data from each participant. Results: Most (31%) of them had breast cancer, 21% of them had gynaecological tract cancer, around 20% of them had digestive tract cancer. Fatigue was the most (48%) commonly reported symptom, followed by vomiting (36%) and pain (29.3%). Other symptoms like itching, oral mucositis, urinary problems, dyspnoea were experienced by the cancer patients under chemotherapy. Conclusion: This study will help the oncology care team to understand the most common symptoms experienced by cancer patients who underwent chemotherapy. Identification and management of these symptoms will help the cancer patients to have adherence to the treatment.