Introduction: Dyslipidemia plays an important role in the pathogenesis and evolution of critical illness, but limited information exists regarding the lipid metabolism of severe coronavirus disease 2019 (COVID-19) patients in India. Patients with COVID-19 feature hyper inflammation, suffer multiple organ dysfunctions, though if these patients develop dyslipidemia or not are unknown. Aim __ampersandsignamp; Objective: We aimed to investigate if there is any correlation between high-density lipoprotein cholesterol (HDL-c) with serum C-reactive protein (CRP), D-Dimer, and serum ferritin in COVID-19 patients of West Bengal. Methodology: Sixty two patients with COVID-19 detected by RT-PCR admitted in General Medicine isolation ward and COVID block between 19th October and 10th December 2020 of a tertiary care teaching hospital was selected by semi-purposive sampling. Results: There were 40.3% patients in mild, 30.6% in moderate and 29% in the severe category. An increased level of D-dimer 1.4 IQR (0.64,3.27) __ampersandsignmu;g/ml was found in patients with severe disease compared with mild group. Serum ferritin in the severe COVID-19 group was higher than in the mild COVID-19 group (485.6 ng/ml IQR(227.7-798.2)] vs 150.3ng/ml IQR(56.4-249.7). Compared with mild patients, severe COVID-19 patients presented with low HDL-C [median, 48 vs 38.3 P = 0.04] which suggested that low HDL-C may be correlated with the severity of COVID-19 patients. Conclusion: We concluded that low HDLc was associated with the inflammatory response. The hypolipidemia in COVID-19 patients would raise an urgent awareness to clinical physicians in the frontline against this global pandemic.