Introduction: Laparoscopic cholecystectomy (LC) has become the gold standard surgical procedure of choice for disorders involving the gall bladder and biliary tract. There are several intraoperative and postoperative complications associated with LC of which port site infections(PSI) are associated with high morbidity and mortality. The present study was carried out to compare the outcomes with bag and non -bag extraction of gall bladder in terms of the incidence of PSI. Methods: This randomized controlled trial was carried out among 326 adults who underwent LC for two years. The participants were randomized into bag extraction and non-bag extraction groups. Postoperatively, the participants were followed up for one week to evaluate the incidence of PSI. Results: The incidence of PSI among bag extraction was 1.4% compared to 9.1% in the non-bag extraction. The presence of diabetes mellitus, elevated glycosylated haemoglobin and immunocompromised status were proven to be risk factors for PSI. (p__ampersandsignlt;0.001) Conclusion: Since bag extraction is associated with lower rates of infection, it is advisable to follow bag extraction as a routine procedure in all LC surgeries, especially in high-risk groups like diabetes mellitus and immunocompromised states.