Introduction: Drug abuse is a universal and social problem with different harms that fluctuate in society. It has become a subject matter of public worry internationally because it adds potentially to deliberate or undeliberate harm. Hence, it is the responsibility of society to facilitate enforcement agencies to eradicate drug abuse in society at large. Objective: The research study examined the effect of drug abuse among persons with disabilities in society at large. Methods: The study adopted a descriptive survey design. The study sampled 688 respondents. The instrument used for data collection was a structured questionnaire. Cronbach Alpha Reliability Coefficient was used to determine the instruments which yielded reliability coefficients of 0.82. The research questions were answered using mean and standard deviation. The scales use for the questionnaire was Strongly Agree (SA), Agree (A), Disagree (D) and Strongly Disagree with the values of 4, 3, 2 and 1 respectively. These responses were based on positively worded items while the reverse was for the negatively worded items. The average score from coded data (4+3+2+1 =10/4) was 2.50. Results: The findings of the study revealed the causes of drugs abuse among persons with disabilities such as earliest influence to smoke, earliest influence to drink alcohol, unemployment, poor academic performance, parental rejection, family abuse, over-controlling by parents, and depression and anxiety among others. The findings of the study revealed preventive strategies to control drug abuse among persons with disabilities and the society at large, which include: dissemination of laws against drug abusers and the establishment of drug law enforcement agencies to monitor drug abuse offenders. Conclusion: Because of the above findings, it was concluded that government should frequently organize educational programs, media broadcasts, advertisements, seminars aimed at enlightening the youths and persons with disabilities on the dangers and consequences of drug abuse.