Introduction: In the farmlands what has been found to be a common chemical for suicidal attempts are Organophosphate poison. This is common in many of the countries. Organophosphate poison is quite dangerous and can have impact once someone consume. Even the smell of this liquid or touch of the chemical to the skin can have a very harmful effect. Fatal left main carotid artery occlusion is rarely reported in literature. Aim: To study the case of consumption of Chlorpyriphos- cypermethrin combination Case Report: In the present paper we have reported a specific case of a person whose age was 25 years and who consumed a Chlorpyriphos- cypermethrin combination who later developed massive myocardial infarction with an ST-elevation __ampersandsigngt;12 mm in aVR followed by a cardiac arrest. Discussion: Cardiac abnormalities are rare in organophosphorus compound poisoning. The patients have include arrhythmia, heart failure, cardiogenic shock, and sudden death. In those patients, clinical manifestations of damage caused by organophosphorus pesticides to the myocardium vary. Conclusion: During the management of organophosphorus compound poisoning, intensive cardiac monitoring should be considered.