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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">4156</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url"> http://dx.doi.org/10.31782/IJCRR.2021.131930</article-id><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>Hepatic Changes Detected by Non-Invasive Biomarker, FIB4 Score and Transient Elastography in Diabetes Mellitus Patients&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Singh</surname><given-names>Vipin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Singh</surname><given-names>Balvir</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>11</day><month>10</month><year>2021</year></pub-date><volume>9)</volume><issue/><fpage>164</fpage><lpage>172</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Objectives: To study the prevalence of hepatic changes in diabetics, evaluate possible risk factors leading to fibrosis and assess the best non-invasive test in between FIB4 score and TE to diagnose hepatic fibrosis earliest possible. Methods: The study was conducted on 304 patients, attending outdoor, diabetic clinics, patients admitted with deranged liver function test, ultrasonography finding and clinical findings inwards of post graduate department of medicine, during a period from October 2018 to November 2019. Informed consent was taken from the patients and detailed history physical examination and laboratory investigations were carried out. NAFLD was diagnosed based on TE (FibroScan). Results: Among patients screened 204 (67%) have developed hepatic involvement in the form of NAFLD picked up by TE, among this 65(32%) had fatty liver without fibrosis or mild fibrosis. The remaining 139(68%) were divided into different categories like significant fibrosis in 92 (45%), severe fibrosis in 16(8%) and cirrhosis in 31(15%)patients. The severity of NAFLD was associated with the significant increase in mean age group, mean waist-hip ratio, mean BMI, mean fasting blood sugar, mean HbA1C and mean triglyceride. Conclusion: To detect the earliest changes of NAFLD patients of diabetes mellitus should undergo liver function tests, FIB4 scoring, ultrasonography of liver and tissue elastography. Prior detection with the help of these non-invasive tests will help in the prevention of fatal complications like cirrhosis, carcinoma of the liver without the potential risk of liver biopsy in unselected patients and also help in altering the disease course..&#13;
</p></abstract><kwd-group><kwd>Diabetes mellitus</kwd><kwd> FIB4 score</kwd><kwd> NAFLD</kwd><kwd> Transientelastography</kwd><kwd> Ultrasonography</kwd><kwd> Fasting blood sugar</kwd></kwd-group></article-meta></front></article>
