Introduction: Primary ophthalmic tumours are well known, but the eye is a rare site for disseminated malignancy. The eye and orbit can get affected by cancer due to the direct effect of metastatic neoplastic infiltration or compression or by circulating anti-bodies involving paraneoplastic retinal degeneration. Aim: The present study aims to objectify the ocular manifestations in systemic malignancies. Methodology: This cross-sectional study was conducted on patients presenting with systemic malignancies to the out-patient department of Krishna Hospital Karad, Maharashtra, from December 2018 to May 2020. Result: Ophthalmic manifestations were seen in 21.77% of patients with systemic malignancies. Conclusion: All patients with systemic malignancies (primary and metastatic) should undergo a thorough ophthalmic examination regularly to prevent visual loss.