Introduction: Stress plays a vital role in alterations in the structure and function of suprarenal glands which may have related to suicidal behaviour. Suicide is the complex interaction of biological, psychological, socio-economic and environmental factors in India and all around the world. The adrenal glands are a pair of life-saving endocrine glands of the human body composed of two parts, the cortex and the medulla. The cortex consists of three zones which are zona glomerulosa, zona fasciculata and zona reticularis. The secretions of these zones are corticosteroids which are responsible for sustaining life against stress and fear. Aims and Objectives: The present study aims to analyze the micrometric changes of zone wise proportion of suprarenal glands such as the zona glomerulosa, zona fasciculata, zona reticularis and medulla in hanging and poison death autopsy cases in different age groups. Methodology: Study Design: Analytical -observational Study. Study setting: The samples were collected from Post mortem centre at Sri Venkateswara hospital, Chittoor district and divided into three age groups as 20-30, 30-40, 40-50 years. A study was done at Peoples Education Society Institute of Medical Scienc es and Research, Kuppam. Chittoor District. The thickness of zona glomerulosa, zona fasciculata, zona reticularis and medulla of the adrenal samples were measured with stage and ocular micrometre by calibration and results were compared between hanging(sudden death) and poison death(delayed death) autopsy cases. Sample Size: 186 adrenals from 93 cases (52 hanging and 41 poison cases). Sampling Technique: Simple random sampling Inclusion Criteria: Both genders of hanging and poison death autopsy cases, three age groups 20-30 years, 30-40 years and 40-50 years and time of autopsy in between 12-24 hours after death were included. Exclusion Criteria: The adrenal abnormalities, burns cases, chronic debilitating illness, Accident cases, decomposed autopsy cases, pregnant women, age group less than 20 and more than 50years, commence of autopsy less than 12 hrs and more than 24 hrs were excluded. Results: In the present study we found that the volume of zona glomerulosa, zona fasciculata, zona reticulars and medulla of right and left adrenal gland were significantly high in poison suicidal case in the age group of 41-50 years, when compared to other two groups. There was no significant difference in zona reticular and medullary volume of both right and left adrenal glands in the age group of 31-40 years. Measurement of zona glomerulosa in the age group 31-40 years right gland show significantly decreased in poison suicidal cases when compared to hanging case but left gland statistically not significant. Conclusion: The left and right adrenal gland volume of zona glomerulosa, zona fasciculata, zona reticular and medulla were significantly high in poison suicidal cases in the age group of 41-50 years and the measurement of zona glomerulosa in the age group 31-40 years right gland show significantly decreased in poison suicidal cases.