Objective: Evaluate the effect of cervical spine manipulation therapy in patients suffering from migraine headaches. Methodology: It was a randomized control trial. Total 62 Subjects suffering from migraine headache and fulfilling the international classification of headache disorders-3 (International headache society) were included in the study. The trial started with 40 participants and in the experimental group, there were 20 participants, with mean age 31.10__ampersandsignplusmn;6.54 and 20 participants in the control group, with mean age 25.9__ampersandsignplusmn;4.19. Group A received cervical spine manipulation therapy (CSMT) and group B received sham manipulation, thrice per week for 2 weeks. The subjects were asked to fill headache impact test, headache disability index questionnaire, and VAS pre and post-intervention. Descriptive statistics were conducted by means and standard deviations for variables like age, gender, visual analogue scale (VAS), and headache impact test (HIT), and headache disability index (HDI). Paired t-test was used to compare the pre and post-treatment values of the groups for statistical significance. An independent t-test was used to compare both groups. Result: The findings obtained by comparing both groups were, VAS reduced significantly after 2 weeks (MD= -1.27; 95% CI -2.05 to -.48; p=0.002), HIT reduced significantly after 2 weeks (MD= -8.86; 95% CI -11.34 to -6.39; p__ampersandsignlt;0.001) and also significant reduction seen in HDI variables (MD= -8.48; 95% CI -0.01 to -12.08; p=.003). Conclusion: The study demonstrated that cervical spine manipulation therapy is an effective treatment and could significantly reduce the headache pain intensity in migraine sufferers. There was a statistically significant difference of different variables found between groups.