Introduction: Infections in transplant patients may be missed as they do not present with the usual clinical features. This leads to a delay in the diagnosis and thereby resulting in delayed treatment. Atypical organisms are also responsible for a variety of infections in these immunosuppressed individuals. The following case illustrates these points. Aim: To report an unusual manifestation of cryptococcal infection. Case Report: This is a case of a 63-year post-renal transplant lady. Three years after the transplant, she presented with a headache. CNS examination did not reveal any abnormality. Non-contrast CT showed well-defined hypodense collection measuring 2.8x 4.1x 3.5 in the right suboccipital region deep to the muscular plane with erosion and defect in the subjacent right occipital bone. Pus culture showed cryptococcus. She underwent drainage of abscess and surgery for osteomyelitis. She received 3 weeks of treatment with liposomal amphotericin B, followed by oral fluconazole. Discussion: Bone involvement occurs in only 5% of cases of cryptococcus. It most often affects the lumbar spine or lower extremities and rarely at other sites. Conclusion: It is important to be aware of this entity especially when managing immune-compromised individuals.