Introduction: Estimation of individual drug components from the multidrug combination tablet is considered a quite tedious task. Moreover, the combination of Bilastine and Montelukast in the oral tablet dosage form is recently launched in the market for the treatment of allergic rhinitis associated with asthma in adults. Further, no reliable method with precise and accurate quantification is available for simultaneous estimation of both drugs. Aim: Development and validation of a rapid, simple, precise yet reliable method for simultaneous estimation of Bilastine and Montelukast from the bulk mixture and a tablet formulation. Methodology: The analysis was performed on a high-performance liquid chromatographic system using Hypersil BDS C-18 column as a stationary phase and triethylamine buffer: Acetonitrile as a mobile phase operated in a gradient mode. The flow rate of the mobile phase was 1.0 ml/min with 40__ampersandsigndeg;C column oven temperature and 10__ampersandsigndeg;C autosampler temperature. Injection volume for all samples was fixed at 10 __ampersandsignmicro;l and the spectrum was recorded at 220nm. Result: The retention time of Bilastine and Montelukast was 1.67 and 7.43 min respectively and the run time for 1 sample analysis was 13 min. The calibration standards show a good linear relationship with R2value of0.99966for Bilastine and 0.99929 for Montelukast. Conclusion: The observations recorded proved that the proposed analytical method is reliable for accurate, precise and rapid quantification of both drugs from the bulk drug as well as pharmaceutical dosage forms.