Introduction: Sepsis is having a rapid advancement as a disease process requiring immediate adjustments in therapy. Corrrect identification of disease severity is absolutely important for treatment, reducing and preventing complications, envisaging prognosis and mortality. Objective: The objective of the present study is to study clinical and laboratory parameters of patients with severe sepsis and septic shock. We have also planned to calculate Acute Physiology and Chronic Health Evaluation-II score (APACHE-II). We have undertaken an Echocardiographic evaluation of cardiac functions. Assessment of cardiac biomarkers like Troponin-T and creatine phosphokinase myocardial band (CPK-MB) have also been attempted in this study. Methodology: This was a prospective, observational descriptive cohort study. The Sample size was calculated based on the Prevalence of Severe Sepsis and Septic Shock. Result: In the present study, it was observed that higher CPK-MB levels and positive Troponin-T were associated with significant mortality. Raised CPK-MB levels were associated with sepsis and septic shock. Positive Troponin-T and raised CPK-MB levels also indicate myocardial injury leading to coronary insufficiency in patients with the diagnosis of sepsis and septic shock. Conclusion: Troponin is frequently elevated in critically ill patients; more research is desirable on the diagnostic and prognostic significance and its possible implication in patients with sepsis septic shock.