Introduction: Poly-trauma injury due to Two Wheelers road traffic accidents is emerging as an epidemic worldwide. Aims: Study the magnitude of poly-trauma injury due to Two Wheelers driver__ampersandsignrsquo;s road traffic accident. Effect of use of the helmet in pattern and severity of injuries. Effects of alcohol intake on incidence and severity of injuries. Methodology: This was a prospective-epidemiological study. Study of 250 polytrauma patients (two-wheeler driver) admitted at the trauma centre, M.G.M. medical college and M.Y. Hospital Indore. All patients aged __ampersandsigngt;18 years with a history of polytrauma injury due to road traffic accidents were included in the study. Results: GCS score was significantly higher in helmet users. Fewer helmet users had an AIS __ampersandsignge;3 over the head/neck, face, thorax, and extremities, compared with without helmet users. A lower Injury Severity Score was also observed in motorcyclists with helmet use. When analyzing four subgroups of trauma patients, the Patient wears a helmet and alcoholic (n=21) compare with the Patient not wear a helmet and alcoholic (n=97) Glasgow Coma Scale relationship (p-value __ampersandsignlt;0.0001) and ISS relationship (p-value 0.3199). Patient wear helmet and non-alcoholic (n=25) compare with Patient not wear helmet and non-alcoholic (n=107) GCS relationship (p-value = 0.0005) and ISS relationship (p-value = 0.5719). Conclusions: Motorcycle helmet users also had a better GCS score and a lower ISS score. A study found that alcohol intoxication did not impact injury severity or injury pattern.