Introduction: Unilateral tibiofemoral osteoarthritis (OA) of the knee is the most common musculoskeletal impairment among the geriatric population and is associated with pain, quadriceps weakness, functional disability and progressive deformity. Quadriceps weakness is an early clinical finding which plays a major role in disease progression. Presently interventions are focused on pain relief and quadriceps reactivation on a subjective basis. Hence, physical therapists must succour these individuals at an early stage and objectively reactivate the quadriceps mechanism. This paper highlights the importance of visual biofeedback in the form of a __ampersandsignldquo;modified sphygmomanometer__ampersandsignrdquo; in retraining quadriceps reactivation and retaining the functional status in individuals with unilateral tibiofemoral osteoarthritis. Objective: To provide an objective re-learning to regain quadriceps muscle strength in individuals with unilateral tibiofemoral osteoarthritis Methodology: It was a case series where 23 individuals in the age group of 35-65 years reporting to the orthopaedic outpatient department were recruited. 12 individuals who fulfilled the selection criteria were included in the study and were observed for 4 weeks. 2 individuals lost their follow up during treatment. After obtaining the oral and written consent basic demographic details, quadriceps isometric strength (Using modified sphygmomanometer in mm/hg), Visual analogue scale for pain (VAS) and Lysholm__ampersandsignrsquo;s knee scoring scale was measured initially and after 4 weeks. Statistics: Wilcoxon signed-rank test was performed to observe the impact of biofeedback based on the pre and post-analysis. Female individuals were found to be more when compared to male individuals. Results: Based on the analysis it was found that there was a significant reduction of pain, improved quadriceps isometric strength and functional outcome following the intervention. Conclusion: It may be concluded that the __ampersandsignldquo;modified sphygmomanometer__ampersandsignrdquo; may be used as a visual biofeedback tool in relearning ing the quadriceps activation objectively in individuals with unilateral tibiofemoral osteoarthritis.