Today, infertility has become more common among young adults due to various reasons which are not easy to determine. The prevalence varies significantly in different parts of the world, ranging sparingly from less than 5% to over 30%. The recent trending cause estimated is the depression and stress due to occupational work. Infertility caused by depression and stress may further cause depression which again worsens the condition. This being the social problem, mass attention has to be achieved in terms of research for resolving it. Many researchers explained the neurophysiology of stress-induced infertility and its probable treatment whereas the exact reason and solution is still a question. In this review, we focus on the neurophysiology, infertility experienced by different occupational workers and the management of stress-induced infertility. A structured and orderly means were undertaken as a key aspect for the systematic literature review.