Introduction and Importance: Spindle cell carcinoma (SpCC) of the lung is a rare type of lung malignancy with a poor prognosis. Only a limited number of cases have been reported worldwide and no established treatment protocol is available at present. Case Presentation: We report a case of a 71-year-old elderly lady, incidentally detected with a lung mass on routine medical evaluation. Preoperative biopsy was suggestive of non-small cell lung cancer, PET-CT was suggestive of localised disease with no mediastinal lymph node. The patient underwent modified uniportal VATS left lower lobectomy with systemic mediastinal lymph node dissection. Postoperative biopsy was suggestive of spindle cell carcinoma lung (pT3N0). At 6 months follow-up, the patient is doing well. Conclusion: We report the first case of successful modified uniportal VATS assisted surgical resection in this poor prognostic type of lung cancer.