Introduction: Nowadays Hypothyroidism is quite common. It results in many problems which ultimately hampers the quality of life. It is a common endocrine disorder in general practice. A textbook describes the classical hypothyroid state thus, the patients face looks grotesquely swollen and eyelids may be so infiltrated that the skin beneath hangs in sacs. The present study aims to study the magnitude and association of subclinical hypothyroidism in individuals having risk factors. (Females with age more than 50 years old and family history of hypothyroidism). Method: This is a Cross-sectional, observational hospital-based study design. The study was conducted on patients attending the medicine outpatient department in Krishna Hospital and Medical Research Centre, Karad. The study duration was from Oc tober 2018 to March 2020 (18 months). Result: A significant association between smoking and subclinical hypothyroidism was found (p __ampersandsignlt; .05). It was observed that a comparatively larger proportion of subjects who consumed tobacco (smokeless form) developed subclinical hypothyroidism, but the statistical significance could not be established (p __ampersandsigngt; .05). Subclinical hypothyroidism was observed significantly more among the subjects with a body mass index of more than 25 kg/m2 (p __ampersandsignlt; .05). Conclusion: Present study provides valuable information regarding the presence of subclinical hypothyroidism in a significant proportion of subjects in context with the Indian population.