Background: Pigmentary epithelial detachment is classified based on its contents into drusenoid, serous, vascularized, or mixed. It may have ocular and/or systemic involvement. Management options in modern medicine have not been proven effective, hence alternative options may be sought. Case Report: A 70-year-old male who presented with the blurring of vision in his right eye (OD) and diminished vision in his left eye (OS), and who was previously diagnosed with serous PED and who had undergone multiple rounds of LASER photocoagulation, is presented here. He reported for eight rounds of inpatient Ayurvedic management, which involved administering oral medicines and external therapies for both eyes and the head. Results: Improvement in visual acuity fundus photography and optical coherence tomography scanning was noted throughout the eight courses of treatment. Conclusion: The main aim of management was to restore vision as much as possible while giving the patient a better quality of life. This study illustrates that cases of serous PED with cystoid macular oedema can be successfully managed using Ayurveda, and these treatments can be considered as an alternative option.