Introduction: Laryngoscopy and tracheal intubation are considered the most noxious stimuli, leading to adverse hemodynamic pressor response, especially in cardiovascular compromised patients, necessitating the need to attenuate the pressor responses. Aim: To study the effects of pregabalin in attenuating the variations in heart rate and blood pressure and relieving anxiety and providing sedation. Methods: Sixty adult patients between 18-60yrs of both gender of ASA status I and II scheduled for elective surgeries under General anaesthesia satisfying the inclusion criteria were selected and randomly allocated into 2 groups- Group A (Pregabalin 300mg orally) and Group B (Placebo) by closed envelope method. Parameters like SBP, DBP, HR, MAP, SPO2 were noted down. 60 minutes after giving the drug, the Sedation score and Anxiety score were noted down. Results: After premedication (90 minutes later) with oral Pregabalin 300mg, sedation score, anxiety score, heart rate, systolic blood pressure, diastolic blood pressure, MAP was significantly reduced Pregabalin group than in the placebo group at intubation. Hence pregabalin proved to be effective in blunting the hemodynamic stress response to laryngoscopy and intubation compared to the control group. There was no incidence of bradycardia or hypotension intraoperatively in any group. There was postoperative sedation in the pregabalin group, but it did not interfere with the patient__ampersandsignrsquo;s recovery. The patients in the pregabalin group were less anxious, quiet and comfortable before and after the surgery. Conclusion: Oral administration of pregabalin 300mg effectively suppressed the cardiovascular response to laryngoscopy and intubation. Pregabalin provided better anxiolysis and sedation without any change in the respiratory pattern compared to the placebo tablet.