Introduction: Dental implants (DI) are being widely used for replacing missing teeth and literature reports showed successful results of DI supported prostheses in partial and complete edentulous rehabilitations. However, knowledge and awareness pertaining to these treatment modalities among patients with and without missing teeth need to be evaluated. Objective: This Cross-sectional observational research aimed to assess and compare the knowledge and awareness on prosthetic rehabilitation with dental implants among dentate and partially / completely edentulous adults. Methods: Self-administeredstructured questionnaire was used to collect the information pertaining to the knowledge and awareness of DI from 500 adults (Group 1: Partially / completely edentulous subjects n=250, Group 2: Dentulous subjects n=250). Further their attitude towards replacement and restoration of missing teeth were also assessed. Responses were tabulated and data was analysed using Chi-Square test and Fisher__ampersandsignrsquo;s exact test. Result: 53.2 % of group 1subjects and 47.6% of group 2 were aware of dental implants (p__ampersandsigngt;0.05). Nevertheless, the latter group had better knowledge and information on DI (surgical placement, DI failure) than the former group (P__ampersandsignlt;0.001). The majority of the dentulous subjects were willing for the DI procedure than the other group (P__ampersandsignlt;0.001). Conclusion: Within the limitations of the study, there is a need to disseminate better knowledge, raise awareness on DI and eliminate the associated misconceptions, thereby facilitating the general population to take maximum advantage of these novel biomaterials to serve the dual purpose of aesthetics and function.