Introduction: Many researchers have described the progression of genetically based differences in personality among sex groups and components of the genetics of individual differences in their masculinity and femininity within each sex group. This has made the basis, for both legal and humanitarian purposes. Aims and objectives: The study was aimed to measure, compare and distinguish the sexual dimorphism in the bizygomatic distance and dimensions of maxillary sinuses on Cone Beam Computed Tomography (CBCT) images and to evaluate their reliability in sex determination that might serve as evidence in forensics. Methodology: Bilateral maxillary sinus CBCT images were obtained for 30 patients, 15 males and 15 females. Bizygomatic distance and maxillary sinus dimensions such as length, height, width, area, perimeter and volume were measured and evaluated. The data obtained was then subjected to descriptive statistical analysis followed by an Independent t-test and One-way ANOVA test to arrive at the results. Results: Comparison between CBCT images of male and female groups showed statistically significant differences in bizygoMatic distance and means of both the right and left maxillary sinus length, height, area, volume and left perimeter with P0.05. Conclusion: Sex determination with few linear measurements of bizygomatic distance and maxillary sinus dimensions was possible among the study population. It was found that males had wider bizygomatic distance and larger sized maxillary sinus when compared to females. Hence this study positively recommends the use of bizygomatic distance and maxillary sinus dimensions for sex determination in the field of forensics.