Introduction: The bonding of existing heat-cured soft liners with nanoparticles reinforced denture base resins remain unclear. Therefore, this study was undertaken to evaluate and compare the tensile bond strength of heat-cured acrylic and silicone-based soft liners with conventional, 5% TiO2 and 7% ZrO2 nanoparticles reinforced PMMA resins in polymerized and unpolymerized forms. Materials __ampersandsignamp; Methods: One hundred and twenty samples were fabricated with dimensions of 10__ampersandsigntimes;10__ampersandsigntimes;3 mm and divided into Polymerized and Unpolymerized groups. It further consisted of twelve subgroups in which heat-cured acrylic-based (Super-Soft) and heat-cured silicone-based soft liner (Molloplast-B) were bonded with conventional, 5% TiO2 and 7% ZrO2 reinforced PMMA resins in polymerized and unpolymerized forms. All the samples were thermocycling for 5000 cycles between the baths of 50 and 550 for 30 seconds dwell time. Tensile bond strength was determined with Autograph Universal Testing Machine, at a crosshead speed of 5 mm/min. Results: The mean and the standard deviation (SD) were calculated for each group. An unpaired t-test was used for statistical analysis. P-value was kept __ampersandsignlt; 0.05. The tensile bond strength of Group A1 (3.36 kg/cm2 ) and Group B1 (3.97 kg/cm2 ) was not within the clinically acceptable range when compared to (4.5 kg/cm2 ). All other groups showed acceptable bond strength. Conclusion: Super soft liner bonded significantly with conventional, 5% TiO2 and 7% ZrO2 nanoparticles reinforced denture base resins in unpolymerized form. Molloplast-B bonded significantly with conventional and 7%ZrO2 nanoparticles reinforced denture base resin in both polymerized and unpolymerized form. Bonding of 5%TiO2 nanoparticle reinforced denture base resin with Molloplast-B was significantly better in unpolymerized form than the polymerized one.