Introduction: Surgical site infections (SSIs) have plagued surgeons since time immemorial. They are important causes of morbidity and mortality and also account for additional costs. The unrestrained and rapidly spreading resistance to the available array of antimicrobials further contribute to the existing problem. Aim: The study was undertaken to estimate the incidence of SSI, identify the risk factors, study the pathogens and their antimicrobial susceptibility pattern. Methodology: This prospective study was conducted for 2 years which included 500 surgical cases. Surgical wounds were graded and samples were collected from the depth of the wound and sent to the laboratory for culture and sensitivity. Identification and antimicrobial susceptibility testing of the isolates were performed by the Vitek-2 (BioMerieux) method. Also, methicillin-resistant Staphylococcus aureus (MRSA) and __ampersandsignbeta;-lactamase production were noted by the Vitek-2 method. Results: The incidence of SSI was found to be 14% (70/500). The risk factors associated were increasing age, co-morbidities like diabetes, prolonged preoperative hospital stay, type of surgeries (emergency surgery) and a class of wound. The common est organism isolated was S. aureus (31.6%), followed by K. pneumonia (26.6%). Twenty-eight (28%) of S. aureus isolates were MRSA and 64.7% of Gram-negative isolates were __ampersandsignbeta;-lactamase producers. Conclusion: The incidence of SSI is higher in developing nations. Although SSI cannot be eliminated the reduction of the rate of infection to minimal can have significant benefits by reducing the wastage of healthcare resources, patient morbidity and mortality.