Aim: The leukoplakia, erythro-leukoplakia and oral verrucous hyperplasia are premalignant lesions found in the oral cavity. Erythroleukoplakia is an uncommon painless precancerous lesion found in the oral cavity. The erythro-leukoplakia is often seen in the oral mucosa, vermillion and gums. The aetiology of erythro-leukoplakia is often variable and usually associated with cigarette smoking, alcoholism, infections and other agents. Case Report: A 35-year-old man presented with complaints of burning sensation in the mouth for two months. Oral cavity examinations revealed a reddish-whitish lesion on the right side buccal mucosa. The patient underwent complete surgical excision of the erythro-leukoplakia from the oral cavity. Results: Biopsy from the lesion is mandatory to rule out malignant transformation and the histopathological examination, in this case, showed dysplastic changes. Conclusion: The diagnosis of erythro-leukoplakia is based on the clinical presentations and histopathological reports. Clinicians should perform the oral cavity examination properly and alert for the patient__ampersandsignrsquo;s addiction to smoking and alcohol consumption. The treatment of choice is surgery and it should be initiated early for preventing malignant transformation.