Objective: To evaluate the prevalence of Polycystic ovarian syndrome (PCOS) and the risk factor profile among medical students. Methods: This was a cross-sectional study carried out among the 117 MBBS students of IMS __ampersandsignamp; SUM Hospital, Bhubaneswar staying at the institutional hostel. Pre-existing hypothyroid was present in 8 students and were excluded from the study. They belonged to the age group of 17 to 25. Data was collected regarding risk factors of PCOS from 109 students by adopting a self-designed questionnaire method. PCOS was diagnosed in the study population as per AE-PCOS (2006) society. Results: In our study prevalence of PCOS was 9.17%. The mean age of the population was 20.68__ampersandsignplusmn;2.06. The average age of menarche was 12.86__ampersandsignplusmn;1.58. The mean BMI of the population was 21.89__ampersandsignplusmn;4.54. On chi-square analysis of different risk factors of PCOS, overweight and obesity, W/H ratio had a significant association with PCOS with p values of 0.00 and 0.00 respectively. Conclusions: A simple questionnaire-based study can be used as an efficient and cost-effective tool for the screening of PCOS and identification of risk factors present in a target population.