Aim: Evaluation of antibacterial efficacy of the methanolic leaf extract of Oroxylum indicum against isolated MDR strains viz. Acinetobacter sp., Citrobacter sp., Enterobacter sp., Escherichia coli, Klebsiella pneumonia, Proteus Vulgaris, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus fecalis causing urinary tract infections (UTI). Methods: Pathogenic bacteria were isolated and identified using the routine microbiological procedure. All the bacteria were MDR as determined from the antibiotic sensitivity test. Agar well diffusion and microbroth dilution methods were used for determining antibacterial efficacy and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was of O. indicums methanolic leaf extract were determined. Cord blood lymphocytes. were used to determine, the in vitro toxicity of the leaf extracts. Results: The leaf extract of O. indicum exhibited good antibacterial activity against both Gram-positive and Gram-negative MDR bacteria. The MIC value of the plant extract ranges from 0.19 to 0.78 mg/ml and the MBC value ranges from 0.78 to 1.56 mg/ ml with all the isolated bacterial pathogens. Plant extracts were found to be very effective against these MDR strains. The plant extract also revealed no toxicity even at a very high concentration of 1800 mg/l with lymphocytes isolated from the cord blood. Surprisingly, the MIC value was found to be 600 mg/l with lymphocytes. Conclusion: O. indiucm__ampersandsignrsquo;s methanolic leaf extract can be used as a potential antibacterial drug. Similarly, other medicinal plants can also be explored for their possible antibacterial efficacy over the antibiotic resistance problem.