Introduction: Antidepressants are used primarily for managing depression and anxiety disorder. With the advent of a newer class of antidepressants with fewer adverse effects, changes in prescription patterns are expected. Aim: To study the current trends of utilization patterns of antidepressant drugs in a tertiary care teaching hospital of Odisha. Methods: A cross-sectional, observational study done in the Pharmacology Department in collaboration with Mental Health Institute (Centre of Excellence) of Sriram Chandra Bhanja (SCB) Medical College and Hospital, Cuttack from September 2017 to September 2019. The study participants were patients irrespective of age and sex, who were prescribed at least one antidepressant drug. Data was collected by interviewing the patients or attendants in a predesigned case record form and was analyzed using Microsoft Excel and SPSS v.20. Results: The number of patients included in the study was 180; among them, females were 55% and 45% were males. The mean age was 47.5 __ampersandsignplusmn; 6.7 years. Eighty-two per cent were outpatients and 18% were inpatients. SSRIs (selective serotonin reuptake inhibitors) were the most common class of antidepressants, among the prescribed drugs followed by SNRIs (serotonin and norepinephrine reuptake inhibitors). The most commonly prescribed antidepressant drug was Sertraline followed by escort citalopram. Most of the patients (more than half) were receiving antidepressants for non-depressive disorders. Conclusion: SSRIs was the most common class of antidepressant used and Sertraline, Escitalopram were the most common medication prescribed for depressive and non-depressive disorders