Background: Non- specific neck pain is the most common health concern among the general population. It leads to functional disabilities of upper limb and pain. Assortment of approaches includes manual therapy has been used for the management of neck pain. Improving Grip strength, reducing functional disabilities of upper limb and reducing pain intensity are important objectives in the treatment of non-specific neck pain. Methods: A randomized, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessors in which patients were randomly allocated into 2 groups; Experimental group (n=26) and Control group (n=26). Patients in experimental group were received the cervical manipulation session; hot pack and TENS for two weeks. Patients in control group were received the hot pack and TENS alone for two weeks Participants were recruited from different clinics and hospitals of Hisar. The outcomes were DASH Score and hand grip strength. All subjects were evaluated at the baseline and post session (after 2 weeks). Results: A total of 52 subjects were participated in the study, including 18 males and 33 females. The mean ages of the subjects were 33.05 years old. Data analysis was done by using paired t __ampersandsignndash;test. This study resulted that the grip strength and DASH Score after the intervention were significantly improved in experimental group as compared to control group. In addition, the performance of hand grip strength [left (p__ampersandsignle;0.000) (95% CI= -13.11, -9.85) and right (p__ampersandsignle;0.000) (95% CI= -12.57, -9.85] and upper limb functions [DASH Score (p__ampersandsignle;0.000) (95% CI= -14.25, -19.46] was superior in experimental group as compared to that of the control group. Ethics and Dissemination: The proposed examination was done after moral endorsement from the Institutional Ethics Committee, Departmental Research Committee, and B.O.S. __ampersandsignamp; R. of the Department of physiotherapy, G.J.U.S__ampersandsignamp;T, Hisar in September 2019, Vide letter no. PTY/2019/1014, dated 11.09.19. Conclusion: Cervical manipulation can improve the Hand grip strength and upper limb functions in non-specific neck pain.