Introduction: Cervical radiculopathy (CR) is a dysfunction of a nerve root in the cervical spine, is a broad disorder with several mechanisms of pathology. The average annual age-adjusted incidence rate of CR is 83/ 100,000 for the population in its entirety. There is a paucity of literature about the effectiveness of two ended slider Neurodynamic technique in CR. Objective: To compare the effect of two ended slider Neurodynamic technique along with conventional physiotherapy and conventional physiotherapy alone in patients with CR. METHODS: Total 58 patients included. Patients were evaluated before, after 2 weeks and post intervention for pain intensity and disability. Data were statistically analyzed at the significance level of __ampersandsignlt;0.05 using SPSS 15 version. Both groups (control and experimental) received conventional physiotherapy, in addition, the experimental group also received two ended Neurodynamic techniques. Results: One way ANOVA test applied for intragroup comparison and there were statistically significant differences in mean VAS and NDI in both the groups during 4-week intervention. An Independent t-test was applied between-group comparisons and there was statistically significant differences between the control group and experimental group in a mean difference of VAS and NDI during 4-week intervention. Conclusion: Conventional physiotherapy and two ended slider neurodynamic technique along with conventional physiotherapy is effective for improving pain and reducing disability. However, two ended slider neurodynamic technique along with conventional physiotherapy is more effective for reducing pain and disability in patients with CR.