Introduction: Lumbar strain is characterized as pain subsequently arising in the region between the lower rib margin and the proximal thighs. However, relapses and recurrences are normal, occurring within six months in about 40% of patients. Studies of physical therapy for lumbar strain are heterogeneous because the intervention method differs, it can include education, exercises, manipulation, as well as modalities such as heat. Transcutaneous Electrical Nerve Stimulation (TENS) and Muscle Energy Technique (MET) are widely used physiotherapy techniques to reduce unilateral lumbar strain. It would be interesting to study the treatment outcome when these two techniques have combined. Objective: The present study aimed to evaluate the effectiveness of TENS with MET on quadratus lumborum in acute unilateral lumbar strain. Methods: In the total of 30 volunteers including males and females with no history of musculoskeletal disease has been selected based on the specific inclusion and exclusion criteria__ampersandsignrsquo;s. They were recruited for the study based on unilateral back pain experiencing around or near lumbar and thoracolumbar segments and positive muscle length tests for erector spinae and quadratus lumborum. All the subjects were assigned into three groups, Group-1 patients undergone TENS treatment, Group-2 patients treated by MET and Group-3 patients were treated by a combination of TENS with MET in the lumbar spine. All these treatments were given five consecutive days a week for a total of three weeks. Pain intensity and discomfort were evaluated before and after the treatment programme. The outcome of the treatment was measured after three weeks from each patient__ampersandsignrsquo;s pain and disability using the Numerical Pain Rating Scale (NPRS) and Modified Oswestry Disability Questionnaire (MODI) were considered for assessment and analysis. Results: There was a reduction in disability index and pain were observed when TENS, MET and TENS with MET treatments. However, the combined treatment of TENS with MET showed a significant reduction (p__ampersandsignlt;0.01 and p__ampersandsignlt;0.001) in disability index and pain when compared to the groups treated with TENS and MET individually. Conclusion: The results of the present study indicated that MET along with TENS can be used as an effective therapeutic maneuver to reduce pain intensity and disability improvement.