Introduction: Leucorrhoea or vaginal discharge is a common complaint among women of reproductive age. Reproductive tract infections originate in the lower genital tract as vaginitis or cervicitis. In conventional medicine, the available treatment is anti-bacterial and antimicrobial, which though effective, has side effects. Objective: The study was conducted to evaluate the therapeutic efficacy and safety of an Unani formulation in leucorrhoea. Methodology: This prospective, single-centre, pre-and post-treatment clinical study was conducted in patients (n=30) of abnormal vaginal discharge from the Dept. of Ilmul Qabalat Wa Amraze Niswan, National Institute of Unani Medicine, Hospital, Ben Bengaluru. Patients received 6g powder of polyherbal formulation (Orchis latifolia L., Phaseolus mungo L., Bambusa arundinacea Retz, Portulaca oleracea L., Pistacia lentiscus L. and Boswellia serrata Roxb) twice daily after meals with water for 21 days. The outcome parameters included vaginal symptom scale (VSS) score for leucorrhoea and associated symptoms and visual analog scale (VAS) to assess low backache (LBA). Data analysis were done using paired proportion test and the Students __ampersandsignlsquo;t__ampersandsignrsquo; test. Results: Out of 30 patients, 25(83.3%), 4(13.3%) and 1(3.3%) showed relieved, partially relieved and no relief in the symptoms respectively. The total VSS score pre-and post-treatment was 33.03__ampersandsignplusmn;3.26 and 19.63__ampersandsignplusmn;5.47 respectively. The polyherbal formulation showed a significant difference after treatment in alleviating signs and symptoms of leucorrhoea (p __ampersandsignlt;0.001) and VAS score for LBA at each follow-up. No side effects were noted. Conclusion: The polyherbal formulation was effective in the management of leucorrhoea.