Introduction: Autism Spectrum Disorder (ASD) is a range of neurodevelopmental related mental disorder which affects the individual__ampersandsignrsquo;s social interactions, communication and also causing the comorbid condition of repetitive behaviour, self-injurious behaviour, and developmental delays. It has been identified that mothers having children with autism have a higher level of parenting-related stresses and longing for better physical, social and mental health. Meaning of life comprises of __ampersandsignldquo;Who are we?, Why are we here ?, What is the purpose of our life? and what is the reason we are living for ?__ampersandsignrdquo; in the context of scientific theories, philosophical and theological explanations. Mothers with special children spend most of their life by providing supportive care to their children and fail to realize their meaning of life. Methods: To understand the purpose of life of mothers who are having children with ASD, The Meaning of Life Questionnaire developed by Steger M. F(2006) was administered to 15 mothers who are having children with ASD followed by a semi-structured interview. An overall perceptive was reported in this study. Result: The result indicates that there was no significant difference in presence and search state in the meaning of life of mothers having children with ASD. Conclusion: The participants from this study disclosed that they have not valued the meaning and purpose in life which can be addressed by psychological counselling and intervention.